Cachexia is a complex metabolic syndrome associated with an underlying illness (such as cancer) and characterized by loss of muscle with or without loss of fat mass 1. Improved approaches for detecting the onset and evolution of muscle wasting would help to manage wasting syndromes and facilitate early intervention 2. As metabolites produced from tissue breakdown are likely to be a sensitive indicator of muscle wasting, urine samples were collected since several end products of muscle catabolism are specifically excreted in urine 2. A total of 77 urine samples were collected being 47 of them patients with cachexia, and 30 control patients. All one-dimensional NMR spectra of urine samples were acquired and then the metabolites were detected and quantified, i.e. for each metabolite its concentration was measured.